Our Essential Prenatal results are now published

May 8, 2026, 1:01 AM•ritual

Hi, Nima Alamdari here, Ritual's Chief Science Officer.

I’m excited to share that our landmark clinical trial on Essential Prenatal is now

published in Frontiers in Nutrition, a peer-reviewed scientific journal. At Ritual, we believe that pregnancy is a high-care, high-trust category, and this publication represents an important milestone in our ongoing effort to deliver a higher standard of support. We’re living in a time where terms like “science-backed” and “clinically studied” are often used loosely. Peer review is different. It requires external experts to rigorously assess the study design, methodology, and findings before publication. It brings transparency to how a product performs in the body—not just how it’s marketed. So what did the study find? This university-led 24-week, randomized, controlled trial showed that using methylated folate (5-MTHF) instead of folic acid as the folate source in a prenatal multivitamin maintained maternal and fetal folate status with less unmetabolized folic acid, or UMFA, concentrations in maternal blood and placenta, compared to a leading prenatal with folic acid. In other words, 5-MTHF was found to be at least as effective as folic acid for maintaining maternal and fetal folate status, while reducing circulating UMFA. Why does this matter? Folate is a critical nutrient for pregnancy, and must be in a form the body can readily use. Folic acid, the synthetic form, requires conversion before it becomes biologically active, and higher intakes can lead to unmetabolized folic acid circulating in the body. This study shows that Essential Prenatal’s form of folate is effectively used during pregnancy while helping to limit excess unmetabolized folic acid. More broadly, it reinforces our commitment to rigorous clinical research and high scientific standards, with our evidence validated through peer review—a process that remains rare in the supplement industry. We are proud to be the number one best-selling prenatal backed by its own human clinical study, and to continue investing in the level of evidence women deserve. More studies are on the way. Cheers, Dr. Nima Alamdari PhD Chief Scientific Officer

Read the Study in Frontiers: Full Article

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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